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KMID : 0381219770090030029
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Journal of RIMSK
1977 Volume.9 No. 3 p.29 ~ p.38
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A Sodium Contents of Various Organs in Hemorrhagic Shock Treated with Adrenergic Drugs
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Abstract
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The alteration of the sodium contents in the various organs of experimental dogs in the state of hemorrhagic shock was consequentively observed by the raidoactive 24Na dilution method after administration of norepinephrine, isoproterenol and phenoxybenzamine.
The following results were obtained:
1. In the group of norepinephrine administration, there was a significant increase of the sodium contents in the liver, representative of retention of blood flows. And there was a noticeable decrease of the sodium contents in the kidney, indicative of marked renal vascular contraction, and a gradual decrease of the sodium contents in the muscle on account of a remarkable disturb-ance of blood flow.
2. In the isoproterenol administered group, it showed an increase of the sodium contents in the liver, highly suggestive of an improvement of blood flow.
3. In the phenoxybenzamine administered group, it revealed an increase of the sodium contents in the kidney, but a little alteration inn the other organs. This fact leads one to a recognition that the drug is a selective renal sympathetic blocking agent.
4. The 24Na content of various organs were influenced by adrenergic drugs according to their organ specificities.
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